Genetically-altered goats produce less allergenic milk
β-Lactoglobulin (BLG) is a dominant allergen present in the milk of goats and other ungulates, although it is not found in human breast milk. Thus, the presence of BLG restricts the consumption of goat’s milk by humans. In the present study, we examined whether the disruption of the BLG gene in goats by homologous recombination (HR) reduced BLG content in goat’s milk and decreased the allergic response to milk. [We generated] two transgenic goats possessing a BLG knockout allele or site-specific hLA [human α-lactalbumin] integration allele. [node:read-more:link]